1: Gomes FA, Flores RA, Bruxel MA, da Silva FN, Moreira ELG, Zoccal DB, Prediger RD, Rafacho A. Glucose homeostasis is not affected in a murine model of Parkinson’s disease induced by 6-OHDA. Front Neurosc.  doi: 10.3389/fnins.2018.01020

2: Inacio M, Rafacho A, Camaforte NAP, Teixeira P, Vareda PMP, Violato NM, Bosqueiro JR. Prevention of elevation in plasma triacylglycerol with high-dose bezafibrate treatment abolishes insulin resistance and attenuates glucose intolerance induced by short-term treatment with dexamethasone in rats.  Int J Endocrinol.  2018:3257812. doi: 10.1155/2018/3257812.

3: Motta K, Gomes PR, Sulis PM, Bordin S, Rafacho A. Dexamethasone Administration During Late Gestation Has No Major Impact on Lipid Metabolism, But Reduces Newborn Survival Rate in Wistar Rats. Front Physiol. | doi: 10.3389/fphys.2018.00783

4: Remor AP, da Silva RA, de Matos FJ, Glaser V, de Paula Martins R, Ghisoni K, da Luz Scheffer D, Andia DC, Portinho D, de Souza AP, de Oliveira PA, Prediger RD, Torres AI, Linhares RMM, Walz R, Ronsoni MF, Hohl A, Rafacho A, Aguiar AS Jr, De Paul AL, Latini A.  Chronic Metabolic Derangement-Induced Cognitive Deficits and Neurotoxicity Are Associated with REST Inactivation. Mol Neurobiol.  doi: 10.1007/s12035-018-1175-9. PMID: 29948953.

 1: Ferreira FBD, Dos Santos C, Bruxel MA, Nunes EA, Spiller F, Rafacho A. Glucose homeostasis in two degrees of sepsis lethality induced by caecum ligation and puncture in mice. Int J Exp Pathol. 2017. doi: 10.1111/iep.12255. PubMed PMID: 29226508.

2: Sulis PM, Motta K, Barbosa AM, Besen MH, da Silva JS, Nunes EA, Rafacho A. Impact of Fish Oil Supplementation and Interruption of Fructose Ingestion on Glucose and Lipid Homeostasis of Rats Drinking Different Concentrations of Fructose. Biomed Res Int. 2017;2017:4378328. doi: 10.1155/2017/4378328. PubMed PMID: 28929113.

3: Romero-Zerbo SY, Ruz-Maldonado I, Espinosa-Jiménez V, Rafacho A, Gómez-Conde AI, Sánchez-Salido L, Cobo-Vuilleumier N, Gauthier BR, Tinahones FJ, Persaud SJ, Bermúdez-Silva FJ. The cannabinoid ligand LH-21 reduces anxiety and improves glucose handling in diet-induced obese pre-diabetic mice. Sci Rep. 2017;7(1):3946. doi: 10.1038/s41598-017-03292-w. PubMed PMID: 28638091.

5: Cappelli APG, Zoppi CC, Silveira LR, Batista TM, Paula FM, da Silva PMR, Rafacho A, Barbosa-Sampaio HC, Boschero AC, Carneiro EM. Reduced glucose-induced insulin secretion in low-protein-fed rats is associated with altered pancreatic islets redox status. J Cell Physiol. 2018;233(1):486-496. doi:10.1002/jcp.25908. PubMed PMID: 28370189.

1. Pinto-Fochi ME, Pytlowanciv EZ, Reame V, Rafacho A, Ribeiro DL, Taboga SR, Góes RM. A high-fat diet fed during different periods of life impairs steroidogenesis of rat Leydig cells. Reproduction. 2016 Dec;152(6):795-808. PubMed PMID: 27679864.

2. Abrantes AAA, Rafacho A, Rivero ERC, Mariano FV, Siqueira FM, Gondak RO. Tissue integrity, costs and time associated with different agents for histological bone preparation. Microsc Res Tech. 2016 nov; DOI: 10.1002/jemt.22798

3. Pasieka A, Rafacho A. Impact of glucocorticoid excess on glucose tolerance: clinical and preclinical evidence. Metabolites 2016, 6(3), 24; doi:10.3390/metabo6030024

4. Battiston FG, Dos Santos C, Barbosa AM, Sehnem S, Leonel EC, Taboga SR, Anselmo-Franci JA, Lima FB, Rafacho A. Glucose homeostasis in rats treated with 4-vinylcyclohexene diepoxide is not worsened by dexamethasone treatment. J Steroid Biochem Mol Biol. 2016; S0960-0760(16)30170-4. doi:10.1016/j.jsbmb.2016.06.001

5. Barbosa AM, Francisco Pde C, Motta K, Chagas TR, Dos Santos C, Rafacho ANunes EA. Fish oil supplementation attenuates changes in plasma lipids caused by dexamethasone treatment in rats. Appl Physiol Nutr Metab. 2016;41(4):382-90. doi: 10.1139/apnm-2015-0487

1. Nunes EA, Rafacho A. Implications of palmitoleic acid (palmitoleate) on glucose homeostasis, insulin resistance and diabetes. Curr Drug Targets. DOI: 10.2174/1389450117666151209120345

2. Protzek AO, Rezende LF, Costa-Júnior JM, Ferreira SM, Cappelli AP, Paula FM, Souza JC, Kurauti MA, Carneiro EM, Rafacho A, Boschero AC. Hyperinsulinemia caused by dexamethasone treatment is associated with reduced insulin clearance and lower hepatic activity of insulin-degrading enzyme. J Steroid Biochem Mol Biol. 2015; doi: 10.1016/j.jsbmb.2015.09.020.

3. Rafacho A, Nunes EA, Bordin, S. How much we know about the attenuation of insulin signaling in the adipose tissue caused by glucocorticoid treatment? Inflammation & Cell Signaling. 2015; 2: e879. doi: 10.14800/ics.879

4. Rafacho A. Canagliflozin in the treatment of diabetes: Perspectives. Diabesity. 2015 1: 7-10. doi:10.15562/diabesity.2015.8

5. Silva SA, Gobbo MG, Pinto-Fochi ME, Rafacho A, Taboga SR, Almeida EA, Góes RM, Ribeiro DL. Prostate hyperplasia caused by long-term obesity is characterized by high deposition of extracellular matrix and increased content of MMP-9 and VEGF. Int J Exp Pathol. 2015 96(1):21-30. doi: 10.1111/iep.12107

6. Fernandes et al., Effects of prebiotic and synbiotic supplementation on inflammatory markers and anthropometric indices after Roux-en-Y gastric bypass: a randomized, triple blind, placebo-controlled pilot study. Journal of Clinical Gastroenterology (Online), 2015.

7. Rocha et al. Selective loads periodization attenuates biochemical disturbances and enhances performance in female futsal players during competitive season. Motriz: Revista de Educação Física (Online), 2015.

8. Camargo et al. Individuals with Hematological Malignancies Before Undergoing Chemotherapy Present Oxidative Stress Parameters and Acute Phase Proteins Correlated with Nutritional Status. Nutrition and Cancer, v. 1, p. 1-9, 2015.

9. Motta K, Barbosa AM, Bobinski F, Boschero AC, Rafacho A. JNK and IKKβ phosphorylation is reduced by glucocorticoids in adipose tissue from insulin-resistant rats. J Steroid Biochem Mol Biol. 2015 145:1-12. doi: 10.1016/j.jsbmb.2014.09.024.


1. Glucocorticoid treatment and endocrine pancreas function: implications for glucose homeostasis, insulin resistance and diabetes. Rafacho A, Ortsäter H, Nadal A, Quesada I. J Endocrinol. 2014 Dec;223(3):R49-R62. Epub 2014 Sep 30. Review.

2. Age- and gender-related changes in glucose homeostasis in glucocorticoid-treated rats. Santos C, Ferreira FBD, Gonçalves-Neto LM, Taboga SR, Boschero AC, Rafacho A. Can J Physiol & Pharmacol. 2014 Oct;92(10):867-78. doi: 10.1139/cjpp-2014-0259.

3. Augmented b-cell function and mass in glucocorticoid-treated rodents are associated with increased islet Ir-/AKT/mTOR and decreased AMPK/ACC and AS160 signaling. Protzek AOP, Costa-Júnior J, Rezende L, Santos GJ, Araújo T, Vettorazzi G, Ortis F, Carneiro EM, Rafacho A & Boschero AC. Int J Endocrinol. 2014; 2014:983453. doi: 10.1155/2014/983453.

4. Disruption of glucose tolerance caused by glucocorticoid excess in rats is partially prevented, but not attenuated, by arjunolic acid. Gonçalves-Neto LM, Ferreira FBD, Souza L, Santos C, Boschero AC, Facundo V, Santos ARS, Nunes EA, Rafacho A. Ind J Exper Biol. 2014 Oct;52(10):972-82.

5. Long-term dexamethasone treatment alters the histomorphology of acini cells in rat parotid and submandibular glands. Biguetti BB, Assis GF, Vieira DC, Violato NM, Cestari TM, Taga R, Bosqueiro JR, Rafacho A. Int J Exp Pathol. 2014 Oct;95(5):351-63. doi.:10.1111/iep

6. Pancreatic alpha-cell dysfunction contributes to the disruption of glucose homeostasis and compensatory insulin hypersecretion in glucocorticoid-treated rats. Rafacho A, Gonçalves-Neto LM, Santos-Silva JC, Alonso-Magdalena P, Merino B, Taboga SR, Carneiro EM, Boschero AC, Nadal A and Quesada I. Plos One. 9(4):e93531. doi: 10.1371/journal.pone.0093531. 

7. Higher insulin sensitivity and impaired insulin secretion in cachetic solid Erlich tumour-bearing mice. Violato, NM, Rafacho, A, Boschero AC and Bosqueiro JR. Horm Metab Res. 46(9):615-20. doi: 10.1055/s-0034-1370967.

8. Effects of glucocorticoids and exercise on pancreatic b-cell function and diabetes development: comments on Breaudry and Riddel. Rafacho ADiabetes Metab. Res & Rev. 2014 Feb;30(2):120-1. doi: 10.1002/dmrr.2473. 

9. Liraglutide counteracts obesity and glucose intolerance in a mouse model of glucocorticoid-induced metabolic syndrome. Fransson L, Dos Santos C, Wolbert P, Sjöholm A, Rafacho A, Ortsäter H. Diabetol Metab Syndr. 2014 Jan 14;6(1):3. doi:10.1186/1758-5996-6-3

10. Kryczyk et al. Exercise and Shark Liver Oil Supplementation Reduce Tumor Growth and Cancer Cachexia in Walker 256 Tumor Bearing Rats. Journal of Cancer Science & Therapy, v. 6, p. 87-93, 2014.


1. Glucose intolerance induced by glucocorticoid excess is further impaired by co-administration with beta-hydroxy beta-methylbutyrate in rats. Nunes, EA, Gonçalves-Neto LM, Ferreira FBD, Santos C, Fernandes LC, Boschero AC, Calder PC, Rafacho A. Applied Physiology, Nutrition, and Metabolism. doi: 10.1139/apnm-2012-0456

2. Glucose homeostasis in rats exposed to acute intermittent hypoxia. Rafacho A, Gonçalves-Neto LM, Ferreira FBD, Protzek AOP, Boschero AC, Nunes EA, Zoccal DB. Acta Physiologica. DOI: 10.1111/apha.12118

3. Effects of omega-3 fatty acids on regulatory T cells in hematologic neoplasms. BETIATI, S.B.D. ; OLIVEIRA, P. F. ; CAMARGO, C. Q. ; Nunes, Everson Araújo ; TRINDADE, E. B. S. MRevista Brasileira de Hematologia e Hemoterapia (Impresso), 2013. (in press)

4. Relationship between acute phase proteins and serum fatty acid composition in morbidly obese patients. FERNANDES, R. ; BESERRA, B. T. S. ; CUNHA, R. S. G. ; HILLESHEIM, E. ; CAMARGO, C. Q. ; PEQUITO, D. C. T. ; CASTRO, I. C. ; FERNANDES, Luiz Claudio ; NUNES, E. A. ; TRINDADE, E. B. S. M.  Disease Markers (Print), 2013. (in press)

5. Fish oil decreases C-Reactive Protein/Albumin ratio improving nutritional prognosis and plasma fatty acid profile in colorectal cancer patients. MOCELLIN, M. C. ; SILVA, J. A. P. E. ; CAMARGO, C. Q. ; FABRE, M. E. S. ; GEVAERD, S. ; NALIWAIKO, K. ; MORENO, Y. M. F. ; NUNES, E. A. ; TRINDADE, E. B. S. M. Lipids, 2013. (in press)


1. High-fat diet obesity associated with insulin resistance increases cell proliferation, estrogen receptor, and PI3K proteins in rat ventral prostate. Ribeiro DL, Pinto ME, Rafacho A, Bosqueiro JR, Maeda SY, Anselmo-Franci JA, Taboga SR, Góes RM. J Androl. 2012;33(5):854-65.

2. Functional and structural adaptations in the pancreatic α-cell and changes in glucagon signaling during protein malnutrition.  Marroquí L, Batista TM, Gonzalez A, Vieira E, Rafacho A, Colleta SJ, Taboga SR, Boschero AC, Nadal A, Carneiro EM, Quesada I. Endocrinology. 2012;153(4):1663-72. doi: 10.1210/en.2011-1623.

3. Fish oil supplementation improves neutrophil function during cancer chemotherapy. Bonatto SJ, Oliveira HH, Nunes EA, Pequito D, Iagher F, Coelho I, Naliwaiko K, Kryczyk M, Brito GA, Repka J, Sabóia LV, Fukujima G, Calder PC, Fernandes LC. Lipids. 2012;47(4):383-9. doi: 10.1007/s11745-011-3643-0. Epub 2011 Dec 11.

4. Endurance training stimulates growth and survival pathways and the redox balance in rat pancreatic islets. Calegari VC, Abrantes JL, Silveira LR, Paula FM, Costa JM Jr, Rafacho A, Velloso LA, Carneiro EM, Bosqueiro JR, Boschero AC, Zoppi CC. J Appl Physiol. 2012;112(5):711-8. doi: 10.1152/japplphysiol.00318.2011.

5. Bax/Bcl-2 protein expression ratio and leukocyte function are related to reduction of Walker-256 tumor growth after β-hydroxy-β-methylbutyrate (HMB) administration in Wistar rats. Kuczera D, Paro de Oliveira HH, Fonseca Guimarães Fde S, de Lima C, Alves L, Machado AF, Coelho I, Yamaguchi A, Donatti L, Naliwaiko K, Fernandes LC, Nunes EANutr Cancer. 2012;64(2):286-93. doi: 10.1080/01635581.2012.647229.

6. PAF increases phagocytic capacity and superoxide anion production in equine alveolar macrophages and blood neutrophils. Muehlmann LA, Michelotto PV Jr, Nunes EA, Grando FC, da Silva FT, Nishiyama A.  Res Vet Sci. 2012 Aug;93(1):393-7. doi: 10.1016/j.rvsc.2011.07.008.


 1. A role for the putative cannabinoid receptor GPR55 in the islets of Langerhans. Romero-Zerbo SY, Rafacho A, Díaz-Arteaga A, Suárez J, Quesada I, Imbernon M, Ross RA, Dieguez C, Rodríguez de Fonseca F, Nogueiras R, Nadal A, Bermúdez-Silva FJ. J Endocrinol. 2011;211(2):177-85. doi: 10.1530/JOE-11-0166.

2. Tumor growth reduction in Walker 256 tumor-bearing rats performing anaerobic exercise: participation of Bcl-2, Bax, apoptosis, and peroxidation. de Lima C, Alves L, Iagher F, Machado AF, Kryczyk M, Yamazaki RK, Brito GA, Nunes EA, Naliwaiko K, Fernandes LC. Appl Physiol Nutr Metab. 2011;36(4):533-8. doi: 10.1139/h11-047.

3. Insulin signaling proteins in pancreatic islets of insulin-resistant rats induced by glucocorticoid. De Paula FM, Boschero AC, Carneiro EM, Bosqueiro JR, Rafacho ABiol Res. 2011;44(3):251-7. doi: /S0716-97602011000300006.

4. Morphofunctional alterations in endocrine pancreas of short- and long-term dexamethasone-treated rats. Rafacho A, Abrantes JL, Ribeiro DL, Paula FM, Pinto ME, Boschero AC, Bosqueiro JR. Horm Metab Res. 2011;43(4):275-81. doi: 10.1055/s-0030-1269896.

5. Low fish oil intake improves insulin sensitivity, lipid profile and muscle metabolism on insulin resistant MSG-obese rats. Yamazaki RK, Brito GA, Coelho I, Pequitto DC, Yamaguchi AA, Borghetti G, Schiessel DL, Kryczyk M, Machado J, Rocha RE, Aikawa J, Iagher F, Naliwaiko K, Tanhoffer RA, Nunes EA, Fernandes LC. Lipids Health Dis. 2011;28(10):66. doi: 10.1186/1476-511X-10-66.

6. β-Hydroxy-β-methylbutyrate modifies human peripheral blood mononuclear cell proliferation and cytokine production in vitro. Nunes EA, Lomax AR, Noakes PS, Miles EA, Fernandes LC, Calder PC. Nutrition. 2011;27(1):92-9. doi: 10.1016/j.nut.2009.12.008.


1. Walker-256 tumor growth is inhibited by the independent or associative chronic ingestion of shark liver and fish oil: a response linked by the increment of peritoneal macrophages nitrite production in Wistar rats. Belo SR, Iagher F, Bonatto SJ, Naliwaiko K, Calder PC, Nunes EA, Fernandes LC. Nutr Res. 2010;30(11):770-6. doi: 10.1016/j.nutres.2010.09.015.

2. The adaptive compensations in endocrine pancreas from glucocorticoid-treated rats are reversible after the interruption of treatment. Rafacho A, Quallio S, Ribeiro DL, Taboga SR, Paula FM, Boschero AC, Bosqueiro JR. Acta Physiol (Oxf). 2010;200(3):223-35. doi: 10.1111/j.1748-1716.2010.02146.x.

3. Insulin and glucose sensitivity, insulin secretion and beta-cell distribution in endocrine pancreas of the fruit bat Artibeus lituratus. Protzek AO, Rafacho A, Viscelli BA, Bosqueiro JR, Cappelli AP, Paula FM, Boschero AC, Pinheiro EC. Comp Biochem Physiol A Mol Integr Physiol. 2010;157(2):142-8. doi: 10.1016/j.cbpa.2010.05.016.

4. Leucine supplementation augments insulin secretion in pancreatic islets of malnourished mice. Amaral AG, Rafacho A, Machado de Oliveira CA, Batista TM, Ribeiro RA, Latorraca MQ, Boschero AC, Carneiro EM. Pancreas. 2010;39(6):847-55. doi: 10.1097/MPA.0b013e3181d37210.

5. Reduced insulin secretion in protein malnourished mice is associated with multiple changes in the beta-cell stimulus-secretion coupling. Soriano S, Gonzalez A, Marroquí L, Tudurí E, Vieira E, Amaral AG, Batista TM, Rafacho A, Boschero AC, Nadal A, Carneiro EM, Quesada I. Endocrinology. 2010;151(8):3543-54. doi: 10.1210/en.2010-0008.

6. Glargine vs. NPH insulin therapy in pregnancies complicated by diabetes: an observational cohort study. Negrato CA, Rafacho A, Negrato G, Teixeira MF, Araújo CA, Vieira L, Silva CA, Date SK, Demarchi AC, Gomes MB. Diabetes Res Clin Pract. 2010;89(1):46-51. doi: 10.1016/j.diabres.2010.03.015.

7. Lymphocytes transfer [(14)C]-labeled fatty acids to skeletal muscle in culture; modulation by exercise. Brito GA, Nunes EA, Nogata C, Yamazaky RK, Naliwaiko K, Curi R, Fernandes LC. Cell Biochem Funct. 2010;28(4):278-82. doi: 10.1002/cbf.1652.

8. Augmentation of insulin secretion by leucine supplementation in malnourished rats: possible involvement of the phosphatidylinositol 3-phosphate kinase/mammalian target protein of rapamycin pathway. Filiputti E, Rafacho A, Araújo EP, Silveira LR, Trevisan A, Batista TM, Curi R, Velloso LA, Quesada I, Boschero AC, Carneiro EM. Metabolism. 2010;59(5):635-44. doi: 10.1016/j.metabol.2009.09.007.

9. Exercise training prevents hyperinsulinemia, muscular glycogen loss and muscle atrophy induced by dexamethasone treatment. Barel M, Perez OA, Giozzet VA, Rafacho A, Bosqueiro JR, do Amaral SL. Eur J Appl Physiol. 2010;108(5):999-1007. doi: 10.1007/s00421-009-1272-6

10. Involvement of the cholinergic pathway in glucocorticoid-induced hyperinsulinemia in rats. Angelini N, Rafacho A, Boschero AC, Bosqueiro JR. Diabetes Res Clin Pract. 2010;87(2):184-91. doi: 10.1016/j.diabres.2009.11.008.

11. Glucocorticoids in vivo induce both insulin hypersecretion and enhanced glucose sensitivity of stimulus-secretion coupling in isolated rat islets. Rafacho A, Marroquí L, Taboga SR, Abrantes JL, Silveira LR, Boschero AC, Carneiro EM, Bosqueiro JR, Nadal A, Quesada I. Endocrinology. 2010;151(1):85-95. doi: 10.1210/en.2009-0704.